Assistant Professor of Pediatrics and Pathology

 

Education/Training

Undergraduate: Nanchang University
Graduate: Nanchang University, Masters in Microbiology
Graduate: Xiamen University
Internship: Hong Kong University of Science and Technology
Postdoctoral research: University of Utah

 

Areas of Interest and Expertise

Molecular biology of pathogenesis of pediatric solid tumors to identify novel therapeutic targets and treatment strategies

 

Publications

Zhuo R, Kosak KM, Sankar S, Wiles ET, Sun Y, Zhang J, Ayello J, Prestwich GD, Shami PJ, Cairo MS, Lessnick SL and Luo W* Targeting glutathione S-transferase M4 in Ewing sarcoma. Front. Pediatr. 2014, 2: 83. doi: 10.3389/fped.2014.00083 (*Corresponding author)

 

Sankar S, Gomez NC, Bell R, Patel M, Davis IJ, Lessnick SL, and Luo W*. EWS and RE-1 silencing transcription factor inhibit neuronal phenotype development and oncogenic transformation in Ewing sarcoma. Genes Cancer. 2013, 4: 213-223. (*Corresponding author)

 

Luo W, Milash B, Dalley B, Smith R, Zhou H, Dutrow N, Cairns BR, and Lessnick SL. Antibody detection of translocations in Ewing sarcoma. EMBO Mol. Med. 2012, 4: 1-9.

 

Luo W, Kinsey M, Schiffman JD and Lessnick SL. Glutathione S-transferases in pediatric cancer. Front. Pediatr. 1: 39. doi: 10.3389/fonc.2011.00039

 

Luo W, Gangwal K, Sankar S, Boucher KM, Thomas D, and Lessnick SL. GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing’s sarcoma oncogenesis and therapeutic resistance. Oncogene. 2009, 28: 4126-4132.

 

Jiang Y, Luo W, and Howe PH. Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions. Oncogene. 2009, 28: 2999-3007.

 

Luo W, Peterson A, Garcia BA, Coombs G, Kofahl B, Heinrich R, Shabanowitz J, Hunt DF, Yost HJ, and Virshup DM. Protein phosphatase 1 regulates assembly and function of the -catenin degradation complex. EMBO J. 2007, 26: 1511-1521.

 

Luo W, Zou H, Jin L, Lin S, Li Q, Ye Z, Rui H, and Lin SC. Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions. J Biol. Chem. 2005, 280: 5054-5060.

 

Rui Y, Xu Z, Xiong B, Cao Y, Lin S, Zhang M, Chan SC, Luo W, Han Y, Lu Z, Ye Z, Zhou HM, Han J, Meng A, and Lin SC. A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Dev. Cell. 2007,13: 268-282.

 

Rui Y, Xu Z, Lin S, Li Q, Rui H, Luo W, Zhou HM, Cheung PY, Wu Z, Ye Z, Li P, Han J, and Lin SC. Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J. 2004, 23: 4583-4594.

 

Wong CK*, Luo W*, Deng Y, Zou H, Ye Z, and Lin SC. The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms. J Biol. Chem. 2004, 279: 39366-39373.(*Equal authorship)

 

Luo W, Ng WW, Jin LH, Ye Z, Han J, and Lin SC. Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation. J Biol. Chem. 2003, 278: 37451-37458.

 

Luo W and Lin SC. Axin: a master scaffold for multiple signaling pathways. Neurosignals 2004, 13: 99-113.

 

Jin LH, Shao QJ, Luo W, Ye ZY, Li Q, and Lin SC. Detection of point mutations of the Axin1 gene in colorectal cancers. Int J Cancer 2003, 107: 696-699.

 

Luo W, Wang S, and Peng X. Identification of shiga toxin-producing bacteria by a new immuno-capture toxin gene PCR. FEMS Microbiol Lett. 2002, 216: 39-42.

 

Peng X, Luo W, Zhang J, Wang S, and Lin S. Rapid detection of Shigella species in environmental sewage by an immunocapture PCR with universal primers. Appl Environ Microbiol. 2002, 68: 2580-2583.