Research Assistant Professor

 

Education/Training

Undergraduate: SungKyunKwan University
Graduate: Ewha Womans University
Post-Doctoral Fellowship: Albert Einstein College of Medicine

 

Areas of Interest and Expertise

Human cancer immunotherapies in the context of hematopoietic stem cell transplantation and determine the role of microRNAs in hematopoiesis.

 

Publications

Park H, Huang X, Lu C, Cairo MS, Zhou X (2015). miR-146a and miR-146b regulate human dendritic cell apoptosis and cytokine production by targeting of TRAF6 and IRAK1. J. Biol. Chem. 290(5):2831-41

 

Huang X, Park H, Greene J, Pao J, Mulvey E, Zhou SX, Sachdev D, Yee D, Rader C, Albert CM,  Hamby C, Loeb D, Cairo MS, Zhou X (2015). Chimeric Antigen Receptor (CAR) T Cell Immunotherapy for High Risk Sarcomas. PloS One. 10(7):e0133152

 

Park H, Dovas A, Hanna S, Lastrucci C, Cougoule C, Maridonneau-Parini I, Cox D (2014). Tyrosine phosphorylation of WASP by Hck regulates Macrophage Function. J. Biol. Chem. 289(11):7897-906

 

Boimel P, Smirnova T, Zhou Z, Wyckoff J, Park H, Coniglio SJ, Patel P, Qian B, Stanley ER, Bresnick AR, Cox D, Pollard JW, Muller WJ, Condeelis J, Segall JE (2012). Contribution of CXCL12 secretion to invasion of breast cancer cells. Breast Cancer Research. 14(1):R23.

 

Ishihara D, Dovas A, Park H, Issac B, and Cox D (2012). The Chemotactic defect in Wiskott-Aldrich syndrome Macrophages is Due to the Reduced Persistence of Directional Protrusions. PloS One. 7(1):e30033.

 

Kantonen S, Mahankali, M, Hatton N, Henkels KM, Park H, Cox D, Gomez-Cambronero J (2011). A two-step mechanism of leukocyte phagocytosis involves the formation of a novel PLD2-Grb2-WASp protein heterotrimer. Mol. Cell. Biol. 31(22):4524-37.

 

Park H, Dovas A, Cox D (2011). N-WASP. Encyclopedia of Signaling Molecules.

 

Park H, Cox D (2011). Syk regulates multiple signaling pathways leading to CX3CL1 chemotaxis in macrophages. J. Biol. Chem. 286(17):14795-803.

 

Park H, Ishihara D, Cox D (2011). Regulation of tyrosine phosphorylation in macrophage phagocytosis and chemotaxis. Arch. Biochem. Biophys. 510(2):101-11.

 

Yong HY, Hwang JS, Son H, Park HI, Oh ES, Kim HH, Kim do K, Choi WS, Lee BJ, Kim HR, Moon A (2011). Identification of h-ras-specific motif for the activation of invasive signaling program in human breast epithelial cells. Neoplasia. 13(2):98-107.

 

Ryu HY, Lee J, Yang S, Park H, Choi S, Jung KC, Lee ST, Seong JK, Han IO, and Oh ES (2009). Syndecan-2 functions as a docking receptor for pro-matrix metalloproteinase-7 in human colon cancer cells. J. Biol. Chem. 284(51):35692-701.

 

Park H, Cox D (2009). Cdc42 Regulates Fc{gamma} Receptor-mediated Phagocytosis through the Activation and Phosphorylation of WASP and N-WASP. Mol. Biol. Cell 20(21):4500-8.

 

Dovas A, Gevrey JC, Grossi A, Park H, Abou-Kheir W, Cox D (2009). Regulation of podosome dynamics by Wiskott-Aldrich Syndrome protein (WASp) phosphorylation: implication in matrix degradation and chemotaxis in macrophages. J. Cell Sci. 122(Pt 21):3873-82.

 

Lee JH, Park H, Chung H, Choi S, Kim Y, Yoo H, Kim TY, Hann HJ, Seong I, Kim J, Kang KG, Han IO, Oh ES (2009). Syndecan-2 regulates the migratory potential of melanoma cells. J. Biol. Chem. 284(40):27167-75.

 

Choi S, Kim Y, Park H, Han IO, Chung E, Lee SY, Kim YB, Lee JW, Oh ES, Yi JY. (2009). Syndecan-2 overexpression regulates adhesion and migration through cooperation with integrin alpha2. Biochem. Biophys. Res. Commun. 384(2):231-5.

 

Jeon J, Lee H, Park H, Lee JH, Choi S, Hwang J, Han IO, Oh ES. (2007). Phosphorylation of focal adhesion kinase at Tyrosine 407 negatively regulates Ras transformation of fibroblasts. Biochem. Biophys. Res. Commun. 364(4):1062-6.

 

Park H, LimY, Jeon J, Han I, Kim J, Jho EH, Oh ES. (2007). Focal adhesion kinase is negatively regulated by phosphorylation at tyrosine 407. J. Biol. Chem. 282(14):10398-404.

 

Son H, LimY, Kim J, Park H, Han I, Kim W. S, Park S, Bae Y, Oh ES. (2006). Protein Kinase Ca can undergo membrane localization via an alternative Phosphatidylinositol 4,5-bisphosphate-dependent pathway. Arch. Biochem. Biophys. 454;1-6.

 

Choi S, Lee E, Kwon S, Park H, Yi J, Kim S, Han I, Yun Y, Oh ES. (2005). Transmembrane domain induced oligomerization is crucial for the functions of syndecan-2 and –4. J. Biol. Chem. 280;42573-42579.

 

Park H, Han I, Kwon H J, Oh ES. (2005). Focal adhesion kinase regulates syndecan-2-mediated tumorigenic activity of HT1080 fibrosarcoma cells. Cancer Res. 65;9899-9905.

 

LimY, Han I, Jeon J, Park H, Bahk Y, Oh ES. (2004). Focal adhesion kinase phosphorylation at Tyrosine 861 is crucial for ras transformation of fibroblasts. J. Biol. Chem. 279;29060-29065.

 

Han I, Park H, Oh ES. (2004). New insights into syndecan-2 expression and tumorigenic activity in colon carcinoma cells. J. Mol. Histology 35;319-326.

 

Kim Y, Park H, Lim Y, Han I, Kwon HJ, Woods A, Oh ES. (2003). Decreased syndecan-2 expression correlates with trichostatin-A induced-morphological changes and reduced tumorigenic activity in colon carcinoma cells. Oncogene 22;826-830.

 

Park H, Kim Y, Lim Y, Han I, Oh ES. (2002). Syndecan-2 Mediates Adhesion and Proliferation of Colon Carcinoma Cells. J. Biol. Chem. 277;29730-29736.