Director, Sickle Cell Disease Program

 

Education/Training

Undergraduate: City College of New York
Medical School: New York Medical College
Residency: Schneider Children’s Hospital, Long Island Jewish Medical Center
Fellowships: Pediatric Hematology-Oncology Fellowship, St. Jude’s Children’s Research Hospital and the University of Tennessee

 

Board Certifications

National Board of Medical Examiners, 1988
American Board of Pediatrics, 1990
American Sub-Board of Pediatric Hematology-Oncology, 1994, 2000, 2008

 

Areas of Interest and Expertise

Leukemia, Sickle cell Disease, Ataxia-telangiectasia, Coagulation Disorders, Immune Thrombocytopenic purpura

 

Publications

1 Yin C, Sandoval C, Gyeong Hun B. Identification of mutant alleles of JAK3 in pediatric patients with acute lymphoblastic leukemia. Leukemia Lymphoma 22: 1-13, 2014.
2 Gripp K, Curry C, Olney A, Sandoval C, Fisher J, Chong J, Pilchman L, Sahroui R, Stabley D, Sol-Church K. Diamond-Blackfan anemia with mandibulofacial dysostosis is heterogeneous, including the novel DBA genes TSR2 and RPS28. Am J Med Genet 164: 2240-2249, 2014.
3 Keefe E, Eden AN, Pandya S, Islam H, Sandoval C. Burkitt lymphoma masquerading as iron deficiency anemia. Research 1: 764, 2014.
4 Jayabose S, Nowicki TS, Dunbar J, Tugal-Levendoglu O, Ozkaynak MF, Sandoval C. Acquired thrombotic thrombocytopenic purpurain children: A single institution experience. Indian J Pediatr 80: 570-575, 2013.
5 Eden AN, Sandoval C. Iron deficiency in infants and toddlers in the United States. Pediatr Hematol Oncol 29: 704-709, 2012.
6 Sandoval C, Sinaki B, Weiss R, Munoz J, Ozkaynak MF, Tugal O, Jayabose S. Urinary tract infections in pediatric oncology patients with fever and neutropenia. Pediatr Hematol Oncol 29: 68-72, 2012.
7 Seiter K, Shah D, Sandoval C, Liu D, Nadelman RB, Sinaki B, Cuffari C, Shi Q, Abid S, Montecalvo M. Prospective evaluation of 2009 H1N1 influenza A in patients admitted with fever to an oncology unit. Infect Control Hosp Epidemiol 32: 815-817, 2011.
8 Kim BH, Kim M, Yin CH, Jee JG, Sandoval C, Lee H, Bach EA, Hahm DH, Baeg GH. Inhibition of JAK3 alleviates inflammation in monoarthritic rats. Br J Pharmacol 161: 106-118, 2011.
9 Mathew R, Huang J, Katta US, Krishan U, Sandoval C, Gewitz M. Immunosuppressant-induced endothelial damage and pulmonary arterial hypertension. JPHO 33: 55-58, 2011.
10 Kim BH, Jee JG, Yin CH, Sandoval C, Jayabose S, Kitamura D, Bach EA, Baeg GH. NSC114792, a novel small molecule identified through structure-based computational database screening, selectively inhibits JAK3. Mol Cancer 9: 36, 2010.
11 Jayabose S, Dunbar J, Nowicki TS, Tugal O, Ozkaynak MF, Sandoval C. Rituximab therapy to prevent relapse in chronic relapsing thrombotic thrombocytopenic purpura in a child. Pediatr Hematol Oncol 28: 167-172, 2011.
12 Sinaki B, Jayabose S, Sandoval C. Iron deficiency anemia associated with hiatal hernia: case reports and literature review. Clin Pediatr 49: 984-985, 2010.
13 Kim BH, Oh SR, Yin CH, LeeS, Kim EA, Kim MS, Sandoval C, Jayabose S, Lee HK, Baeg GH. MS-1020 is a novel small molecule that selectively inhibits JAK3 activity. Br. J Haematol 148: 132-143, 2010.
14 Sandoval C. Pediatric acute lymphoblastic leukemia: There is no TEL-ing what wonders lie ahead. Leukemia Res 34: 418-419, 2010.
15 Halicka D, Ozkaynak MF, Levendoglu-Tugal O, Sandoval C, Seiter K, Malgarzata K, Traganos F, Jayabose S, Darzynkiewicz Z. DNA damage response as a biomarker in treatment of leukemias. Cell Cycle 8: 1720-1724, 2009.
16 Kim BH, Yin CH, Guo Q, Bach EA, Lee H, Sandoval C, Jayabose S, Ulaczyk-Lesanko A, Hall DG, Baeg GH. A small-molecule compound identified through a cell-based screening inhibits JAK/STAT pathway signaling in human cancer cells. Mol Cancer Ther 9: 2672-2680, 2008.
17 Goldman ID, Min SH, Sandoval C, Kronn D (June 2008) Hereditary Folate Malabsorption in: GeneReviews at GeneTests: Medical Genetics Information Resource [database online]. Copyright, University of Washington, Seattle, 1997-2008. Available at http://www.genetests.org.
18 Nowicki TS, Bjornard K, Kudlowitz D, Sandoval C, Jayabose S. Early recognition of renal toxicity of high-dose methotrexate therapy: a case report. J Pediatr Hematol Oncol 30: 950-952, 2008.
19 Brodsky SV, Sandoval C, Sharma N, Yusuf Y, Facciuto ME, Humphrey M, Yeh YA, Braun A, Melamed M, Finegold MJ. Recurrent nested stromal epithelial tumor of the liver with extrahepatic metastasis. Pediatr Dev Pathol 11: 469-473, 2008.
20 Jayabose S, Pine SR, Ozkaynak MF, Tugal O, Sandoval C. A case of relapsed Down syndrome-associated acute megakaryoblastic leukemia cured with non-myeloablative chemotherapy. Clin Leukemia 1: 309-312, 2007.
21 Nur S, Badr R, Sandoval C, Brudnicki, A, Yeh A. Syndromic presentation of a pleuropulmonary blastoma associated with congenital cystic adenomatoid malformation. A case report. J Pediatr Surg 42: 1772-1775, 2007.
22 Pine SR, Guo Q, Yin C, Jayabose S, Druschel CM, Sandoval C. Incidence and clinical implications of GATA1 mutations in newborns with Down syndrome. Blood 110: 2128-2131; 2007.
23 Zhao R, Min SH, Qiu A, Sakaris A, Goldberg G, Sandoval C, Malatack JJ, Rosenblatt DS, Goldman ID. The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption. Blood 110: 1147-1152; 2007.
24 McFarren A, Jayabose S, Ozkaynak MF, Tugal O, Sandoval C. Cleft palate, bilateral external auditory canal atresia and other midline defects associated with Diamond-Blackfan anemia: case report. J Pediatr Hematol-Oncol 29: 338-340, 2007.
25 Pepper S, Islam HK, Jayabose S, Ozkaynak MF, Tugal O, Sandoval C. Neuroblastoma masquerading as cervical lymphadenitis. J Pediatr Hematol Oncol 29: 260-261; 2007.
26 Sabaawy HE, Sandoval C, Guo Q, Yin C, Kulangara A, Lee J, Wormser G, Jayabose S, Pine SR. Lymphoproliferative clonal origin of AIDS-related non-Hodgkin’s lymphoma. Leukemia Lymphoma 48: 812-815, 2007.
27 Qiu A, Jansen M, Sakaris A, Min SH, Chattopadhyay S, Tsai E, Sandoval C, Zhao R, Akabas MH, Goldman ID. Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell 127: 917-928; 2006.
28 Jayabose S, Levendoglu-Tugal O, Ozkaynak MF, Sandoval C. Recurrent immune thrombocytopenic purpura in children. Pediatr Hematol Oncol 23: 677-682; 2006.
29 Carr E, Jayabose S, Stringel G, Slim M, Ozkaynak MF, Tugal O, Sandoval C. The safety of central line placement prior to treatment of pediatric acute lymphoblastic leukemia. Pediatr Blood Cancer 47: 886-888; 2006.
30 Schroeder SA, Swift M, Sandoval C, Langston C. Interstitial lung disease in patients with ataxia-telangiectasia. Pediatr Pulmonol 39: 537-543, 2005.
31 Pine SR, Guo Q, Yin C, Jayabose S, Levendoglu-Tugal O, Ozkaynak MF, Sandoval C. GATA1 as a new target to detect minimal residual disease in both transient leukemia and megakaryoblastic leukemia of Down syndrome. Leukemia Res 29: 1353-1356, 2005.
32 Ozkaynak MF, Sandoval C, Levendoglu-Tugal O, Jayabose S. A pilot trial of tandem autologous peripheral blood progenitor cell transplantation following high-dose thiotepa and carboplatin in children with poor-risk central nervous system tumors Pediatr Hematol Oncol 21: 635-645, 2004.
33 Jayabose S, Levendoglu-Tugal O, Ozkaynak MF, Visintainer P, Sandoval C. Long-term outcome of chronic idiopathic thrombocytopenic purpura in children. J Pediatr Hematol Oncol 26: 724-726, 2004.
34 Pine SR, Yin CH, Matloub YH, Sabaawy HE, Sandoval C, Levendoglu-Tugal O, Ozkaynak MF, Jayabose S. Detection of CNS leukemia in children with acute lymphoblastic leukemia by real-time PCR. J Mol Diagn 7: 127-132, 2005.
35 Sandoval C, Davis A, Jayabose S. Eyelid mass as the presenting finding in a child with Down syndrome and acute megakaryoblastic leukemia. Pediatrics 115: 810-811, 2005.
36 Sandoval C, Pine SR, Guo Q, Sastry S, Stewart J, Kronn D, Jayabose S. Tetrasomy 21 transient leukemia with a GATA1 mutation in a phenotypically normal trisomy 21 mosaic infant: case report and review of the literature. Pediatr Blood Cancer 44: 85-91, 2005.
37 Sandoval C, Jayabose S, Eden AN. Trends in diagnosis and management of iron deficiency during infancy and early childhood. Hematol Oncol Clin North Am 18: 1423-1438, 2004.
38 Sandoval C, Visintainer P, Ozkaynak MF, Tugal O, Jayabose S. Clinical features and treatment outcomes of 79 infants with immune thrombocytopenic purpura. Pediatr Blood Cancer 42: 109-112, 2004.
39 Sandoval C, Strom K, Stringel G. Laparoscopy in the management of pediatric intra-abdominal tumors. JSLS 8: 115-118, 2004.
40 Sandoval C, Swift M. Cytomegalovirus pneumonitis in a patient with Hodgkin disease and ataxia-telangiectasia. Pediatr Pulmonol 37: 559-560, 2004.
41 Sandoval C, Kutscher M, Jayabose, S, Tenner M. Neurotoxicity of intrathecal methotrexate- magnetic imaging findings. AJNR Am J Neuroradiol 24: 1887-1890, 2003.
42 Jayabose S, Levendoglu-Tugal O, Ozkaynak F, Chao C, Cuccovia B, Sandoval C. The use of vincristine and cyclosporine in childhood thrombotic thrombocytopenic purpura. J Pediatr Hematol Oncol 25: 421-425, 2003.
43 Sandoval C, Katz B, Stringel G, Jayabose S, Lebovics E. Cholelithiasis and choledocholithiasis after sequential cytarabine and asparaginase. J Pediatr Hematol Oncol 25: 637-639, 2003.
44 Franco S, Ozkaynak MF, Sandoval C, Tugal O, Jayabose S, Engelhardt M, Moore MAS. Telomere dynamics in childhood leukemia and solid tumors: a follow-up study. Leukemia 17: 401-410, 2003.
45 Sandoval C, Swift M. Poor outcomes of Hodgkin disease in ataxia-telangiectasia patients. Med Pediatr Oncol 40: 162-166, 2003.
46 Mayer SP, Wiemels JL, Jayabose S, Sandoval C. TEL-AML1 fusion precedes differentiation to pre-B cells in childhood acute lymphoblastic leukemia. Leukemia Res 27: 155-164; 2003.
47 Sandoval C, Garcia C, Visintainer P, Ozkaynak MF, Jayabose S. The usefulness of preoperative screening for bleeding disorders. Clin Pediatr 42: 247-250, 2003.
48 Pine SR, Moy FH, Wiemels JL, Gill RK, Levendoglu-Tugal O, Ozkaynak MF, Sandoval C, Jayabose S. Real-time quantitative PCR- standardized detection of minimal residual disease in pediatric acute lymphoblastic leukemia. J Pediatr Hematol Oncol 25: 103-108. 2003.
49 Mayer SP, Jayabose S, Tugal O, Ozkaynak MF, Rosenblum-Vos L, Sandoval C. Origin of a central nervous system lymphoid neoplasm in an immunocompromised host with acute lymphoblastic leukemia. Leukemia Lymphoma 43: 1881-1884, 2002.
50 Levendoglu-Tugal O, Ozkaynak MF, La Gamma E, Sherbany A, Sandoval C, Jayabose S. Hemophagocytic lymphohistiocytosis presenting with thrombocytopenia in the newborn. J Pediatr Hematol Oncol 24: 405-409, 2002.
51 Sandoval C, Berger E, Ozkaynak MF, Tugal O, Jayabose S. Severe iron deficiency anemia in 42 pediatric patients. Pediatr Hematol Oncol 19: 157-162, 2002.
52 Geller J, Kronn D, Jayabose S, Sandoval C. Hereditary folate malabsorption: Family report and review of the literature. Medicine 81: 51-68, 2002.
53 Sandoval C, Piper J, Mowery-Rushton P, Jayabose S. Fetal-type hepatoblastoma and deletion of chromosome 3 (q11.2q13.2). Cancer Genet Cytogenet 134: 162-164, 2002.
54 Sandoval C, Schantz S, Posey D, Swift M. Parotid and thyroid gland cancers in patients with ataxia-telangiectasia. Pediatr Hematol Oncol 18: 485-490, 2001.
55 Sandoval C, Venkateswaran L, Billups C, Slim M, Jayabose S, Hudson MM. Lymphocyte predominant Hodgkin disease in children. J Pediatr Hematol Oncol 24: 269-273, 2002.
56 Sandoval C, Stringel G, Ozkaynak MF, Tugal O, Jayabose S. Perioperative management in children with sickle cell disease undergoing laparoscopic surgery. J Soc Laparoendosc Surg 6: 29-33, 2002.
57 Sandoval C, Dong S, Visintainer P, Ozkaynak MF, Jayabose S. The clinical and laboratory features of 178 children with recurrent epistaxis. J Pediatr Hematol Oncol 24: 47-49, 2002.
58 Sandoval C, Ozkaynak MF, Tugal O, Jayabose S. Hyperdiploidy in a case of favorable histology Wilms tumor. Cancer Genet Cytogenet 127: 89-90, 2001.
59 Sandoval C, Jayabose S. Mucoepidermoid carcinoma following chemotherapy for childhood acute lymphoblastic leukemia. Pediatr Hematol Oncol 18: 217-220, 2001.
60 Jayabose S, Levendoglu-Tugal O, Giamelli J, Grodin W, Cohn M, Sandoval C, Ozkaynak F, Kubal K, Nosetti M, Uman J, Visintainer P. Total intravenous anesthesia with propofol for painful procedures in children with cancer. J Pediatr Hematol Oncol 23: 290-293, 2001.
61 Backer MV, Kamel N, Sandoval C, Jayabose S, Menodola CE, Backer JM. Overexpression of NM 23-1 enhances responsiveness of IMR-32 human neuroblastoma cells to differentiation stimuli. Anticancer Res 20: 1743-1750, 2000.
62 Sandoval C, Stringel G, Ozkaynak MF, Tugal O, Jayabose S. Laparoscopic splenectomy in pediatric patients with hematologic diseases. J Soc Laparoendosc Surg 4: 117-120, 2000.
63 Sandoval C, Swift M. Appropriate cancer chemotherapy for ataxia-telangiectasia patients. Med Pediatr Oncol 34: 65-66, 2000.
64 Sandoval C, Hudson MH, Ozkaynak MF, Tugal O, Jayabose S. Down syndrome and Hodgkin disease: A brief report. Med Pediatr Oncol 34: 304-305, 2000.
65 .Sandoval C, Mayer SP, Ozkaynak MF, Tugal O, Jayabose S. Trisomy 5 as a sole cytogenetic abnormality in pediatric acute lymphoblastic leukemia. Cancer Genet Cytogenet 118: 69-71, 2000.
66 Jayabose S, Mahmoud M, Levendoglu-Tugal O, Sandoval C, Ozkaynak F, Visintainer P. Corticosteroid prophylaxis for neurologic complications of IVIG therapy in childhood immune thrombocytopenic purpura. J Pediatr Hematol Oncol 21: 514-517, 1999.
67 Sandoval C, Mayer SP, Giamelli J, Farley T, Ozkaynak MF, Tugal O, Jayabose S. Cytogenetic abnormalities during clinical, immunophenotypic, and molecular remission in pediatric acute lymphoblastic leukemia. Cancer Genet Cytogenet 118: 9-13, 2000.
68 Sandoval C, Bolten P, Franco I, Freeman S, Jayabose S. Recurrent urinary tract infections and genitourinary tract abnormalities in the Imerslund-Gräsbeck syndrome. Pediatr Hematol Oncol 17: 331-334, 2000.
69 Mayer SP, Giamelli J, Sandoval C, Roach AS, Ozkaynak MF, Tugal O, Rovera G, Jayabose S. Quantitation of leukemia clone-specific antigen gene rearrangements by a single-step PCR and fluorescence-based detection method. Leukemia 13: 1843-1852, 1999.
70 Sandoval C, Corbi D, Strobino B, Ozkaynak MF, Tugal O, Jayabose S. A randomized, double-blind comparison of single high-dose ondansetron and multiple standard-dose ondansetron in chemotherapy-naïve pediatric oncology patients. Cancer Invest 17: 309-313, 1999.
71 Levendoglu-Tugal O, Weiss R, Ozkaynak MF, Sandoval C, Lentzner B, Jayabose S. T-cell acute lymphoblastic leukemia after renal transplantation in childhood. J Pediatr Hematol Oncol 20: 548-551, 1998
72 Levendoglu-Tugal O, Munoz J, Brudnicki A, Ozkaynak MF, Sandoval C, Jayabose S. Infections due to nontuberculous mycobacteria in children with leukemia. Clin Infect Dis 27: 1227-1230, 1998.
73 Sandoval C, Swift M. Treatment of lymphoid malignancies in patients with ataxia-telangiectasia. Med Pediatr Oncol 31: 491-497, 1998.
74 Sandoval C, Stringel G, Ozkaynak MF, Tugal O, Jayabose S. Isochromosome (7q) in Wilms’ tumor. Cancer Genet Cytogenet 104: 61-65, 1998.
75 Freeman SJ, Parker A, Sandoval C. Multiorgan uptake of Tc-99m MDP in a patient with Stage IV alveolar rhabdomyosarcoma. Clin Nucl Med 23: 385-386, 1998.
76 Engelhardt M, Ozkaynak MF, Drullinsky P, Sandoval C, Tugal O, Jayabose s, Moore MAS. Telomerase activity and telomere length in pediatric patients with malignancies undergoing chemotherapy. Leukemia 12: 13-24, 1998.
77 Sandoval C, Stringel G. Video-assisted thoracoscopy for the diagnosis of mediastinal masses in children. J Soc Laparoendosc Surg 1: 55-59, 1997.
78 Sandoval C, Stringel G, Weisberger J, Jayabose S. Failure of partial splenectomy to ameliorate the anemia of pyruvate kinase deficiency. J Pediatr Surg 32: 641-641, 1997.
79 Jayabose S, Tugal O, Sandoval C, Patel P, Puder D, Lin T, Visintainer P. Clinical and hematologic effects of hydroxyurea in sickle cell disease. J Pediatr 129: 559-565, 1996.
80 Sandoval C, Oiseth S, Slim M, Tugal O, Ozkaynak MF, Brudnicki A, Beneck D, Bostwick H, Jayabose S. Gastric ganglioneuroblastoma: A rare finding in an infant with multifocal ganglioneuroblastoma. J Pediatr Hematol Oncol 18: 409-412, 1996
81 Sandoval C, Meyer WH, Parham DM, Kun LE, Husto HO, Luo X, Pratt CB. Outcome in 43 children presenting with metastatic Ewing’s sarcoma: The St. Jude Children’s Research Hospital Experience, 1962-1992. Med Pediatr Oncol 26: 180-185, 1996.
82 Sandoval C, Parganas E, Adams-Graves P, Wang W, Ihle JN. Lack of alterations in the cytoplasmic domain of the granulocyte colony-stimulating factor receptor in eight cases of severe congenital neutropenia. Blood 85: 852-853, 1995.
83 Wang W, Sandoval C, Arnold B, Head DR, Kearns C, Kuhls T, Nagata S, Ihle J. Congenital neutropenia refractory to hematopoietic growth factors. Int J Pediatr Hematol Oncol 1: 229-234, 1994.
84 Jayabose S, Tugal O, Sandoval C, Li K. Recombinant human granulocyte colony stimulating factor in cyclic neutropenia: Use of a new three day a week regimen. Am J Pediatr Hematol Oncol 16: 338-340, 1994.
85 Sandoval C, Pui C-H, Bowman LC, Hurwitz C, Raimondi SC, Behm FG, Head DR. Secondary acute myeloid leukemia in pediatric patients treated with intercalating topoisomerase II inhibitors, alkylating agents, and irradiation. J Clin Oncol 11: 1039-1045, 1993.
86 Griffin TC, Tomlinson GE, Raimondi SC, Sandoval C, Timmons CF, Rosenfeld C, Carroll AJ, Schneider MR. Childhood acute lymphoblastic leukemia with both t(1;19) and t(9;22). Leukemia 6: 535-540, 1992.
87 Sandoval C, Head DR, Mirro J, Behm FG, Ayers GD, Raimondi SC. The t(9;11) in pediatric de novo and secondary acute myeloblastic leukemia. Leukemia 6: 513-519, 1992.
88 Orlic D, Gill R, Feldschuh R, Quaini F, Malice A, Sandoval C. Molecular mechanism for the inhibitory action of interferon on hematopoiesis. Ann NY Acad Sci 554: 36-48, 1989.